The goal of this set of readings is to hopefully answer the following two questions:
1. How focal to the ATL is the atrophy in semantic dementia?
2. Do semantic deficits correlate specifically with atrophy or hypoperfusion in the ATL?
The answer to these questions will determine how strong the evidence is regarding the link between semantic deficits and ATL dysfunction.
I've included a bunch of papers because I'd like to get as complete a picture as we can. But no need to rush through all of them this weekend, as our next class meeting isn't until Jan. 28th. In the meantime, if I've left off any critical papers, please send me a note, either on- or off-line. I've already heard from Murray Grossman's group (via Jonathan Peelle) in this respect, and this led me to some interesting papers. Any suggestions from the London Group? I noticed a couple of hits from UCL, so I know someone over there is watching... Would very much like input from all the SD experts!
Davies RR, Graham KS, Xuereb JH, Williams GB, Hodges JR.
The human perirhinal cortex and semantic memory.
Eur J Neurosci. 2004 Nov;20(9):2441-6.
Galton CJ, Patterson K, Graham K, Lambon-Ralph MA, Williams G, Antoun N, Sahakian BJ, Hodges JR.
Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia.
Neurology. 2001 Jul 24;57(2):216-25.
Williams GB, Nestor PJ, Hodges JR.
Neural correlates of semantic and behavioural deficits in frontotemporal dementia.
Neuroimage. 2005 Feb 15;24(4):1042-51. Epub 2004 Dec 19.
Grossman M, McMillan C, Moore P, Ding L, Glosser G, Work M, Gee J.
What's in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degeneration.
Brain. 2004 Mar;127(Pt 3):628-49.
Levy DA, Bayley PJ, Squire LR.
The anatomy of semantic knowledge: medial vs. lateral temporal lobe.
Proc Natl Acad Sci U S A. 2004 Apr 27;101(17):6710-5.
Seeley WW, Bauer AM, Miller BL, Gorno-Tempini ML, Kramer JH, Weiner M, Rosen HJ.
The natural history of temporal variant frontotemporal dementia.
Neurology. 2005 Apr 26;64(8):1384-90.
Diehl-Schmid J, Grimmer T, Drzezga A, Bornschein S, Perneczky R, Forstl H, Schwaiger M, Kurz A.
Longitudinal changes of cerebral glucose metabolism in semantic dementia.
Dement Geriatr Cogn Disord. 2006;22(4):346-51.
Diehl J, Grimmer T, Drzezga A, Riemenschneider M, Förstl H, Kurz A.
Cerebral metabolic patterns at early stages of frontotemporal dementia and semantic dementia. A PET study.
Neurobiol Aging. 2004 Sep;25(8):1051-6.
Nestor PJ, Fryer TD, Hodges JR.
Declarative memory impairments in Alzheimer's disease and semantic dementia.
Neuroimage. 2006 Apr 15;30(3):1010-20.
Rogers TT, Hocking J, Noppeney U, Mechelli A, Gorno-Tempini ML, Patterson K, Price CJ. Anterior temporal cortex and semantic memory: reconciling findings from neuropsychology and functional imaging. Cogn Affect Behav Neurosci. 2006 Sep;6(3):201-13.
Yep, looks highly relevant. Thanks Greig!
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